|
gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:3-phosphoinositide-dependent_protein_kinase-1
gptkb:PDPK1
|
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gptkbp:associatedWith
|
gptkb:cancer
gptkb:diabetes
cell survival
cell growth
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodedBy
|
gptkb:PDPK1_gene
|
|
gptkbp:enzymeCommissionNumber
|
EC 2.7.11.1
|
|
gptkbp:fullName
|
gptkb:3-phosphoinositide-dependent_protein_kinase-1
|
|
gptkbp:function
|
serine/threonine kinase
phosphorylates and activates AGC family kinases
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDK1 protein
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_16p13.3
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
63 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:phosphorylates
|
gptkb:AKT1
gptkb:S6K
gptkb:SGK
gptkb:PKC
|
|
gptkbp:regulates
|
activated by PIP3
regulated by phosphorylation
|
|
gptkbp:structure
|
contains PH domain
contains kinase domain
|
|
gptkbp:UniProtID
|
gptkb:O15530
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gptkbp:bfsParent
|
gptkb:PDPK1_gene
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gptkbp:bfsLayer
|
7
|