|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activeSiteResidue
|
ATP binding site
|
|
gptkbp:alternativeSplicing
|
No
|
|
gptkbp:associatedWith
|
Spinocerebellar ataxia type 14
|
|
gptkbp:cofactor
|
gptkb:Calcium
Phospholipid
DAG (diacylglycerol)
|
|
gptkbp:component
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:database
|
GeneCards:PRKCG
HGNC:9400
OMIM:176980
UniProt:P05129
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.13
|
|
gptkbp:fullName
|
Protein kinase C gamma type
|
|
gptkbp:function
|
protein kinase activity
Serine/threonine-protein kinase involved in various cellular processes
|
|
gptkbp:gene
|
gptkb:PRKCG
|
|
gptkbp:GOProcess
|
regulation of cell proliferation
synaptic transmission
|
|
gptkbp:hasIsoform
|
gamma
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P05129 (PKC gamma)
|
|
gptkbp:interactsWith
|
gptkb:PRKCB
gptkb:PRKCE
gptkb:GRIA2
gptkb:DLG4
GABRA1
RACK1
|
|
gptkbp:length
|
697 amino acids
|
|
gptkbp:locatedOnChromosome
|
19q13.42
|
|
gptkbp:molecularWeight
|
78 kDa
|
|
gptkbp:mutationAssociatedWith
|
Associated with SCA14 (Spinocerebellar ataxia type 14)
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Mus musculus Prkcg
Rattus norvegicus Prkcg
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:Signal_transduction
gptkb:Calcium_signaling_pathway
|
|
gptkbp:postTranslationalModification
|
Phosphorylation
Autophosphorylation
|
|
gptkbp:proteinFamily
|
Protein kinase C (PKC) family
|
|
gptkbp:structure
|
Contains 1 AGC-kinase C-terminal domain
Contains 1 C2 domain
Contains 2 C1 domains
|
|
gptkbp:subcellularLocation
|
gptkb:Nucleus
gptkb:Cell_membrane
gptkb:Cytoplasm
|
|
gptkbp:tissue_specificity
|
gptkb:Brain
|
|
gptkbp:UniProtID
|
P05129
|
|
gptkbp:bfsParent
|
gptkb:PKC
|
|
gptkbp:bfsLayer
|
6
|