|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:PSD-95
SAP90
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:synaptic_plasticity
gptkb:autism_spectrum_disorder
epilepsy
memory
schizophrenia
learning
intellectual disability
|
|
gptkbp:conservedIn
|
vertebrates
|
|
gptkbp:discoveredBy
|
researchers in the 1990s
|
|
gptkbp:domain
|
SH3 domain
PDZ domain
GK domain
|
|
gptkbp:encodes
|
gptkb:PSD-95
|
|
gptkbp:Entrez_Gene_ID
|
1742
ENSG00000132535
|
|
gptkbp:expressedIn
|
brain
postsynaptic density
|
|
gptkbp:fullName
|
Discs large homolog 4
|
|
gptkbp:function
|
postsynaptic density protein
synaptic scaffolding protein
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
2898
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DLG4
|
|
gptkbp:interactsWith
|
gptkb:NMDA_receptor
neurexins
SHANK proteins
neuroligins
|
|
gptkbp:length
|
724 amino acids
|
|
gptkbp:locatedOnChromosome
|
17q21.31
|
|
gptkbp:memberOf
|
gptkb:MAGUK_family
|
|
gptkbp:molecularWeight
|
~80 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:autism_spectrum_disorder
intellectual disability
|
|
gptkbp:OMIM
|
602887
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Dlg4
|
|
gptkbp:pathway
|
gptkb:long-term_potentiation
gptkb:synaptic_vesicle_cycle
glutamatergic synapse
|
|
gptkbp:proteinFamily
|
DLG family
|
|
gptkbp:regulates
|
synaptic strength
synaptic signaling
receptor clustering
|
|
gptkbp:subcellularLocation
|
postsynaptic density
|
|
gptkbp:UniProtID
|
P78352
|
|
gptkbp:bfsParent
|
gptkb:P05129_(PKC_gamma)
|
|
gptkbp:bfsLayer
|
7
|