|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:OCT2
solute carrier family 22 member 2
|
|
gptkbp:associatedWith
|
nephrotoxicity
cisplatin-induced kidney injury
|
|
gptkbp:Entrez_Gene_ID
|
6582
ENSG00000196832
|
|
gptkbp:fullName
|
human organic cation transporter 2
|
|
gptkbp:function
|
transports organic cations across cell membranes
|
|
gptkbp:gene
|
gptkb:SLC22A2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
hOCT2
|
|
gptkbp:inhibitedBy
|
gptkb:verapamil
cimetidine
pyrimethamine
quinidine
|
|
gptkbp:locatedOnChromosome
|
gptkb:6q26
|
|
gptkbp:location
|
basolateral membrane of renal proximal tubules
|
|
gptkbp:molecularWeight
|
~63 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:significance
|
genetic variants affect drug response
involved in drug-drug interactions
|
|
gptkbp:substrate
|
gptkb:metformin
gptkb:tetraethylammonium
dopamine
serotonin
creatinine
|
|
gptkbp:tissue_specificity
|
gptkb:kidney
brain
liver
|
|
gptkbp:transmembraneDomains
|
12
|
|
gptkbp:transporterFamily
|
gptkb:SLC22
|
|
gptkbp:UniProtID
|
O15244
|
|
gptkbp:bfsParent
|
gptkb:OCT2
|
|
gptkbp:bfsLayer
|
6
|