|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CSL
CBF1
JkappaRBP
RBP-Jkappa
|
|
gptkbp:associatedWith
|
gptkb:cancer
Adams-Oliver syndrome 3
|
|
gptkbp:conservedIn
|
yes
|
|
gptkbp:discoveredBy
|
Honjo T
|
|
gptkbp:domain
|
C-terminal domain
Rel homology domain
beta-trefoil domain
|
|
gptkbp:Entrez_Gene_ID
|
3516
ENSG00000168214
|
|
gptkbp:fullName
|
Recombination signal binding protein for immunoglobulin kappa J region
|
|
gptkbp:function
|
transcription factor
DNA binding
mediates Notch signaling pathway
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
gptkb:GO:0006355_(regulation_of_transcription,_DNA-templated)
GO:0003700 (DNA-binding transcription factor activity)
|
|
gptkbp:HGNC_ID
|
HGNC:9915
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RBPJ
|
|
gptkbp:interactsWith
|
gptkb:EP300
gptkb:SHARP
gptkb:NOTCH1
gptkb:MAML1
CTBP1
|
|
gptkbp:length
|
500 amino acids
|
|
gptkbp:locatedOnChromosome
|
4
|
|
gptkbp:location
|
4p15.2
|
|
gptkbp:molecularWeight
|
56 kDa
|
|
gptkbp:OMIM
|
602768
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Su(H) (Drosophila melanogaster)
|
|
gptkbp:pathway
|
gptkb:Notch_signaling_pathway
|
|
gptkbp:PDB
|
2FO1
3BRG
3IAG
|
|
gptkbp:RefSeq
|
NM_005349
NP_005340
|
|
gptkbp:regulates
|
transcription of Notch target genes
|
|
gptkbp:requires
|
Notch signaling
|
|
gptkbp:species
|
gptkb:human
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:symbol
|
gptkb:RBPJ
|
|
gptkbp:transcription_regulation
|
acts as repressor or activator depending on context
|
|
gptkbp:UniProtID
|
Q06330
|
|
gptkbp:bfsParent
|
gptkb:human_NOTCH1_gene
|
|
gptkbp:bfsLayer
|
7
|