Statements (47)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
stress
cytokines free radicals ultraviolet irradiation bacterial and viral infections |
| gptkbp:alsoKnownAs |
nuclear factor kappa-light-chain-enhancer of activated B cells pathway
|
| gptkbp:database |
KEGG: hsa04064
Reactome: R-HSA-449147 |
| gptkbp:discoveredBy |
gptkb:David_Baltimore
Ranjan Sen |
| gptkbp:discoveredIn |
1986
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
neurodegenerative diseases autoimmune diseases chronic inflammation |
| https://www.w3.org/2000/01/rdf-schema#label |
NF-kB pathway
|
| gptkbp:inhibitedBy |
IκB proteins
|
| gptkbp:involves |
gptkb:IKK_complex
p50 p52 RelA (p65) RelB c-Rel NF-kB protein complex |
| gptkbp:location |
cytoplasm (inactive state)
nucleus (active state) |
| gptkbp:regulates |
apoptosis
cell proliferation inflammation immune response expression of adhesion molecules expression of cytokines expression of anti-apoptotic genes expression of growth factors |
| gptkbp:relatedTo |
gptkb:MAPK_pathway
gptkb:TNF_signaling_pathway Toll-like receptor signaling interleukin-1 signaling |
| gptkbp:target |
gptkb:aspirin
corticosteroids anti-inflammatory drugs nonsteroidal anti-inflammatory drugs (NSAIDs) |
| gptkbp:bfsParent |
gptkb:NOD-like_receptors
gptkb:vGPCR gptkb:MCV_MC132_protein |
| gptkbp:bfsLayer |
7
|