Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:binds |
NF-κB dimers
|
| gptkbp:contains |
ankyrin repeat domains
|
| gptkbp:degradedBy |
gptkb:proteasome
|
| gptkbp:discoveredIn |
1990s
|
| gptkbp:example |
gptkb:IκBα
BCL3 IκBβ IκBε IκBNS IκBζ |
| gptkbp:fullName |
Inhibitor of kappa B
|
| gptkbp:function |
inhibits NF-κB transcription factors
|
| gptkbp:gene |
NFKBIA (for IκBα)
NFKBIB (for IκBβ) NFKBIE (for IκBε) |
| https://www.w3.org/2000/01/rdf-schema#label |
IκB
|
| gptkbp:location |
gptkb:cytoplasm
|
| gptkbp:memberOf |
gptkb:NF-κB_signaling_pathway
|
| gptkbp:phosphorylates |
gptkb:IKK_complex
|
| gptkbp:prevention |
NF-κB nuclear translocation
|
| gptkbp:regulates |
gptkb:NF-κB_signaling_pathway
|
| gptkbp:relatedTo |
cell survival
inflammation immune response |
| gptkbp:bfsParent |
gptkb:NF-κB_pathway
gptkb:B_cell_receptor_signaling_pathway |
| gptkbp:bfsLayer |
7
|