|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:associatedWith
|
multi-drug resistance
|
|
gptkbp:biosafetyLevel
|
2
|
|
gptkbp:detects
|
PCR
DNA sequencing
|
|
gptkbp:discoveredBy
|
gptkb:Bacteria
gptkb:Klebsiella_pneumoniae
Yong et al.
|
|
gptkbp:discoveredIn
|
2008
|
|
gptkbp:encodedBy
|
blaNDM-1 gene
|
|
gptkbp:enzymeClassification
|
metallo-beta-lactamase
|
|
gptkbp:exceptionsToResistance
|
gptkb:aztreonam
|
|
gptkbp:firstReported
|
gptkb:India
gptkb:United_Kingdom
|
|
gptkbp:foundIn
|
clinical isolates worldwide
|
|
gptkbp:fullName
|
New Delhi metallo-beta-lactamase 1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NDM-1
|
|
gptkbp:impact
|
global health threat
|
|
gptkbp:inhibitedBy
|
gptkb:clavulanic_acid
gptkb:EDTA
|
|
gptkbp:locatedOnChromosome
|
plasmid
|
|
gptkbp:mechanismOfAction
|
hydrolyzes beta-lactam antibiotics
|
|
gptkbp:molecularWeight
|
28 kDa
|
|
gptkbp:namedAfter
|
gptkb:New_Delhi
|
|
gptkbp:publicHealthConcern
|
antibiotic resistance
|
|
gptkbp:publishedIn
|
Lancet Infectious Diseases 2010
|
|
gptkbp:relatedTo
|
gptkb:KPC
gptkb:VIM-1
gptkb:IMP-1
|
|
gptkbp:resistanceGeneFamily
|
MBL (metallo-beta-lactamase)
|
|
gptkbp:resistantTo
|
gptkb:beta-lactam_antibiotics
carbapenem antibiotics
most beta-lactam antibiotics
|
|
gptkbp:riskFactor
|
medical tourism
|
|
gptkbp:sequenceAccession
|
GenBank: FN396876
|
|
gptkbp:spreadTo
|
gptkb:Asia
gptkb:Australia
gptkb:Europe
gptkb:North_America
plasmid-mediated horizontal gene transfer
|
|
gptkbp:structure
|
zinc-dependent active site
|
|
gptkbp:transmissible
|
yes
|
|
gptkbp:treatmentChallenge
|
limited antibiotic options
|
|
gptkbp:WHOConcern
|
critical priority pathogen
|
|
gptkbp:bfsParent
|
gptkb:antimicrobial_resistance_gene_NDM
gptkb:NDM_beta-lactamase
gptkb:IMP-1
gptkb:NDM-type_metallo-beta-lactamases
|
|
gptkbp:bfsLayer
|
8
|