|
gptkbp:instanceOf
|
immune response
Cell
|
|
gptkbp:activatedBy
|
gptkb:interferon-gamma
gptkb:tumor_necrosis_factor_alpha
lipopolysaccharide
|
|
gptkbp:canBePolarizedTo
|
M1 macrophage
M2 macrophage
|
|
gptkbp:discoveredIn
|
1882
|
|
gptkbp:engulfs
|
pathogens
apoptotic cells
cell debris
|
|
gptkbp:expressedIn
|
gptkb:Fc_receptors
pattern recognition receptors
complement receptors
|
|
gptkbp:firstDescribed
|
gptkb:Élie_Metchnikoff
|
|
gptkbp:foundIn
|
vertebrates
tissues
|
|
gptkbp:function
|
phagocytosis
cytokine production
antigen presentation
|
|
gptkbp:hasRole
|
gptkb:cancer
tuberculosis
atherosclerosis
autoimmune diseases
chronic inflammation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Macrophage
|
|
gptkbp:lifespan
|
months to years
|
|
gptkbp:marking
|
gptkb:CD14
CD68
F4/80
|
|
gptkbp:originatedIn
|
gptkb:monocyte
|
|
gptkbp:produces
|
gptkb:interleukin-6
gptkb:tumor_necrosis_factor_alpha
gptkb:interleukin-1
reactive oxygen species
|
|
gptkbp:role
|
inflammation
innate immunity
tissue repair
|
|
gptkbp:size
|
21 micrometers (average)
|
|
gptkbp:subspecies
|
gptkb:microglia
alveolar macrophage
Kupffer cell
osteoclast
splenic macrophage
|
|
gptkbp:bfsParent
|
gptkb:Cells_at_Work!
|
|
gptkbp:bfsLayer
|
4
|