MYC proto-oncogene, bHLH transcription factor
GPTKB entity
Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
tumor suppressor |
| gptkbp:alias |
gptkb:c-Myc
gptkb:MYC |
| gptkbp:associatedWith |
gptkb:Burkitt_lymphoma
multiple cancers |
| gptkbp:binds |
E-box DNA sequences
|
| gptkbp:discoveredBy |
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop |
| gptkbp:discoveredIn |
1979
|
| gptkbp:encodes |
gptkb:c-Myc_protein
|
| gptkbp:Entrez_Gene_ID |
4609
|
| gptkbp:expressedIn |
gptkb:nucleus
|
| gptkbp:formsComplexWith |
gptkb:MAX_protein
|
| gptkbp:function |
regulation of apoptosis
regulation of cell proliferation transcription factor regulation of differentiation |
| gptkbp:HGNC_ID |
7553
|
| https://www.w3.org/2000/01/rdf-schema#label |
MYC proto-oncogene, bHLH transcription factor
|
| gptkbp:involvedIn |
embryonic development
angiogenesis immune response stem cell maintenance metabolic reprogramming cellular transformation |
| gptkbp:locatedOnChromosome |
chromosome 8
8q24.21 |
| gptkbp:mutationAssociatedWith |
oncogenesis
tumorigenesis |
| gptkbp:OMIM |
190080
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
gptkb:Myc
|
| gptkbp:proteinFamily |
basic helix-loop-helix (bHLH) transcription factors
|
| gptkbp:regulates |
metabolism
cell cycle progression cell growth transcriptional activation DNA replication ribosome biogenesis transcriptional repression |
| gptkbp:target |
phosphorylation
acetylation microRNAs ubiquitin-mediated degradation SUMOylation |
| gptkbp:UniProtID |
P01106
|
| gptkbp:bfsParent |
gptkb:HGNC:8583
|
| gptkbp:bfsLayer |
7
|