MYC proto-oncogene, bHLH transcription factor

URI: https://gptkb.org/entity/MYC_proto-oncogene,_bHLH_transcription_factor
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:tumor_suppressor
gptkb:gene
gptkbp:alias gptkb:c-Myc
gptkb:MYC
gptkbp:associatedWith gptkb:Burkitt_lymphoma
multiple cancers
gptkbp:binds E-box DNA sequences
gptkbp:discoveredBy gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
gptkbp:discoveredIn 1979
gptkbp:encodes gptkb:c-Myc_protein
gptkbp:Entrez_Gene_ID 4609
gptkbp:expressedIn gptkb:nucleus
gptkbp:formsComplexWith gptkb:MAX_protein
gptkbp:function gptkb:transcription_factor
regulation of apoptosis
regulation of cell proliferation
regulation of differentiation
gptkbp:HGNC_ID 7553
gptkbp:involvedIn gptkb:immune_response
embryonic development
angiogenesis
stem cell maintenance
metabolic reprogramming
cellular transformation
gptkbp:locatedOnChromosome chromosome 8
8q24.21
gptkbp:mutationAssociatedWith oncogenesis
tumorigenesis
gptkbp:OMIM 190080
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Myc
gptkbp:proteinFamily basic helix-loop-helix (bHLH) transcription factors
gptkbp:regulates metabolism
cell cycle progression
cell growth
transcriptional activation
DNA replication
ribosome biogenesis
transcriptional repression
gptkbp:target phosphorylation
acetylation
microRNAs
ubiquitin-mediated degradation
SUMOylation
gptkbp:UniProtID P01106
gptkbp:bfsParent gptkb:HGNC:8583
gptkb:HGNC:8607
gptkb:MMYC
gptkbp:bfsLayer 8
https://www.w3.org/2000/01/rdf-schema#label MYC proto-oncogene, bHLH transcription factor