|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
CD227
Mucin-1
episialin
|
|
gptkbp:associatedWith
|
gptkb:cancer
pancreatic cancer
|
|
gptkbp:discoveredBy
|
Hilary M. Taylor
|
|
gptkbp:domain
|
SEA domain
tandem repeat domain
|
|
gptkbp:encodedBy
|
MUC1 gene
|
|
gptkbp:Entrez_Gene_ID
|
4582
ENSG00000185499
|
|
gptkbp:expressedIn
|
gastrointestinal tract
mammary gland
genitourinary tract
respiratory tract
epithelial tissues
|
|
gptkbp:firstDescribed
|
1980s
|
|
gptkbp:function
|
cell signaling
formation of protective mucous barrier
protection of epithelial cells
|
|
gptkbp:gene
|
gptkb:MUC1
|
|
gptkbp:hasRole
|
biomarker
immune modulation
|
|
gptkbp:HGNC_ID
|
7508
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MUC1
|
|
gptkbp:interactsWith
|
gptkb:EGFR
gptkb:beta-catenin
galectin-3
|
|
gptkbp:length
|
variable (due to VNTR region)
|
|
gptkbp:locatedOnChromosome
|
1q22
|
|
gptkbp:molecularWeight
|
variable (due to glycosylation)
|
|
gptkbp:mutationAssociatedWith
|
medullary cystic kidney disease type 1
|
|
gptkbp:OMIM
|
158340
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:postTranslationalModification
|
glycosylation
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
transmembrane protein
extracellular domain rich in tandem repeats
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
vaccine development
immunotherapy
monoclonal antibodies
|
|
gptkbp:UniProtID
|
P15941
|
|
gptkbp:bfsParent
|
gptkb:miR-145
gptkb:chromosome_1q22
|
|
gptkbp:bfsLayer
|
7
|