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gptkbp:instanceOf
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gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:B-lymphocyte_antigen_CD20
gptkb:CD20_antigen
B1
|
|
gptkbp:associatedWith
|
leukemia
multiple sclerosis
immune response
B-cell development
|
|
gptkbp:biologicalProcess
|
cell cycle progression
calcium channel activity
regulation of B-cell activation
differentiation of B cells
|
|
gptkbp:compatibleWith
|
gptkb:NK_cells
gptkb:T_cells
monocytes
plasma cells
granulocytes
|
|
gptkbp:discoveredBy
|
Tedder TF
|
|
gptkbp:encodes
|
CD20 protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000156738
931
|
|
gptkbp:expressedIn
|
gptkb:B_cells
B cell differentiation
|
|
gptkbp:firstDescribed
|
1988
|
|
gptkbp:function
|
B-lymphocyte antigen receptor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple transcript variants
|
|
gptkbp:HGNC_ID
|
7319
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MS4A1 gene
|
|
gptkbp:length
|
297 amino acids (CD20 protein)
|
|
gptkbp:locatedOnChromosome
|
chromosome 11
11q12.2
|
|
gptkbp:mutationAssociatedWith
|
autoimmune diseases
immunodeficiency
|
|
gptkbp:numberOfExons
|
8
|
|
gptkbp:OMIM
|
112210
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:lion
gptkb:mouse
right
|
|
gptkbp:product
|
four transmembrane domains
|
|
gptkbp:proteinFamily
|
membrane-spanning 4-domains subfamily A
|
|
gptkbp:significance
|
biomarker for B cells
therapeutic target in autoimmune diseases
therapeutic target in lymphoma
|
|
gptkbp:target
|
gptkb:rituximab
gptkb:ocrelizumab
gptkb:ofatumumab
|
|
gptkbp:UniProtID
|
P11836
|
|
gptkbp:bfsParent
|
gptkb:CD20
|
|
gptkbp:bfsLayer
|
7
|