Statements (56)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:application |
gptkb:gene_therapy
|
| gptkbp:associated_pathologies |
gptkb:anemia
immunodeficiency X-linked agammaglobulinemia |
| gptkbp:associated_with |
ataxia-telangiectasia-like disorder
|
| gptkbp:biological_processes |
telomere maintenance
cell cycle checkpoint regulation cellular response to DNA damage stimulus DNA repair signaling pathway |
| gptkbp:breeding_range |
chromosome 11
|
| gptkbp:cellular_role |
DNA damage sensor
repair factor signal transducer |
| gptkbp:clinical_trial |
biomarker for cancer
|
| gptkbp:conserved_in |
eukaryotes
|
| gptkbp:diseases |
gptkb:Oncology
neurodegeneration |
| gptkbp:function |
DNA repair
|
| gptkbp:functional_domains |
gptkb:BRCT_domain
nuclease domain |
| gptkbp:genetic_studies |
increased cancer risk
|
| gptkbp:genetic_variants |
single nucleotide polymorphisms
copy number variations |
| gptkbp:has_role |
homologous recombination
|
| https://www.w3.org/2000/01/rdf-schema#label |
MRE11 A
|
| gptkbp:initiated_by |
small molecule inhibitors
|
| gptkbp:interacts_with |
gptkb:RAD50
NBS1 |
| gptkbp:involved_in |
double-strand break repair
|
| gptkbp:is_a_tool_for |
gptkb:CRISPR_technology
RNA interference knockout models |
| gptkbp:is_expressed_in |
various tissues
upregulated in tumors downregulated in some cancers |
| gptkbp:located_in |
gptkb:Atom
|
| gptkbp:nutritional_value |
gptkb:BRCA2
gptkb:BRCA1 gptkb:TP53 ATM DNA binding exonuclease activity nuclease activity MRE11 protein complex |
| gptkbp:orthologs |
MRE11 in other species
|
| gptkbp:pathway |
DNA damage response
|
| gptkbp:promoter |
MRE11 family
|
| gptkbp:research_focus |
cell cycle regulation
cancer biology genomic stability |
| gptkbp:therapeutic_targets |
gptkb:cancer_treatment
radiation therapy chemotherapy |
| gptkbp:bfsParent |
gptkb:MRE11
|
| gptkbp:bfsLayer |
8
|