Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
DNA repair
|
| gptkbp:conservation |
eukaryotes
|
| gptkbp:diseases |
gptkb:Oncology
|
| gptkbp:function |
double-strand break repair
|
| gptkbp:genetic_studies |
genetic disorders
|
| gptkbp:has_role |
telomere maintenance
|
| gptkbp:has_variants |
SNPs
|
| https://www.w3.org/2000/01/rdf-schema#label |
RAD50
|
| gptkbp:interacts_with |
gptkb:MRE11
NBS1 |
| gptkbp:involved_in |
homologous recombination
|
| gptkbp:is_essential_for |
genomic stability
|
| gptkbp:is_expressed_in |
gptkb:Brain
ovary testis various tissues bone marrow lymphocytes |
| gptkbp:is_involved_in |
apoptosis regulation
chromosome segregation cellular response to stress cellular senescence tumor suppression non-homologous end joining cellular response to DNA damage cellular response to hypoxia cellular response to ionizing radiation cellular response to oxidative stress cellular response to nutrient deprivation cellular response to UV radiation cellular response to chemical stress cellular response to heat shock DNA damage signaling repair of double-strand breaks repair of interstrand cross-links repair of oxidative DNA damage repair of single-strand breaks DNA replication stress response cellular response to DNA damage stimulus cell cycle checkpoint genome integrity maintenance immunological processes recombination repair repair of DNA adducts repair of replication fork collapse telomere repair |
| gptkbp:is_linked_to |
gptkb:anemia
gptkb:ataxia-telangiectasia |
| gptkbp:is_part_of |
gptkb:MRN_complex
DNA damage response pathway |
| gptkbp:is_regulated_by |
gptkb:ATM_kinase
gptkb:ATR_kinase |
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:located_in |
human chromosome 5
|
| gptkbp:orthologs |
gptkb:mouse
gptkb:yeast |
| gptkbp:bfsParent |
gptkb:MRE11
|
| gptkbp:bfsLayer |
8
|