Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
RAF kinases
|
| gptkbp:alternativeName |
gptkb:Mitogen-activated_protein_kinase_kinase_2
MAP2K2 protein Dual specificity mitogen-activated protein kinase kinase 2 |
| gptkbp:associatedWith |
gptkb:cancer
gptkb:RASopathies |
| gptkbp:domain |
protein kinase domain
|
| gptkbp:encodedBy |
gptkb:MAP2K2_gene
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
serine/threonine-protein kinase activity
|
| gptkbp:inhibitedBy |
gptkb:MEK_inhibitors
|
| gptkbp:involvedIn |
gptkb:MAPK/ERK_signaling_pathway
|
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:molecularWeight |
approximately 45 kDa
|
| gptkbp:orthologIn |
gptkb:Mus_musculus
|
| gptkbp:phosphorylates |
gptkb:ERK1
gptkb:ERK2 Ser222 Ser226 |
| gptkbp:regulates |
cell differentiation
cell proliferation cell survival |
| gptkbp:UniProtID |
P36507
|
| gptkbp:bfsParent |
gptkb:LIN-45_protein
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
MEK-2 protein
|