|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:DPC4
gptkb:Mothers_against_decapentaplegic_homolog_4
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:domain
|
MH1 domain
MH2 domain
|
|
gptkbp:encodedBy
|
gptkb:SMAD4_gene
|
|
gptkbp:Entrez_Gene_ID
|
4089
ENSG00000141646
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
signal transduction
transcription regulation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
6770
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Smad4
|
|
gptkbp:interactsWith
|
TGF-beta receptors
Smad1
Smad2
Smad3
Smad5
Smad8
|
|
gptkbp:involvedIn
|
gptkb:BMP_signaling_pathway
gptkb:TGF-beta_signaling_pathway
|
|
gptkbp:length
|
552
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
chromosome 18q21.2
|
|
gptkbp:memberOf
|
gptkb:SMAD_family
|
|
gptkbp:molecularWeight
|
60 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:juvenile_polyposis_syndrome
colorectal cancer
pancreatic cancer
|
|
gptkbp:OMIM
|
600993
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:1U7V
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
gene expression
|
|
gptkbp:requires
|
apoptosis
embryonic development
cell growth regulation
|
|
gptkbp:UniProtID
|
gptkb:Q13485
|
|
gptkbp:bfsParent
|
gptkb:MADH4
gptkb:SMAD4_gene
gptkb:MH2
|
|
gptkbp:bfsLayer
|
7
|