|
gptkbp:instanceOf
|
gptkb:protein
nuclear receptor
|
|
gptkbp:activatedBy
|
oxysterols
|
|
gptkbp:alternativeName
|
gptkb:NR1H3
gptkb:Liver_X_receptor_alpha
|
|
gptkbp:associatedWith
|
gptkb:diabetes_mellitus
gptkb:metabolic_syndrome
atherosclerosis
|
|
gptkbp:binds
|
gptkb:gene
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:encodedBy
|
gptkb:NR1H3_gene
|
|
gptkbp:expressedIn
|
liver
adipose tissue
macrophages
intestine
|
|
gptkbp:formsHeterodimerWith
|
gptkb:retinoid_X_receptor_(RXR)
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
regulation of cholesterol metabolism
regulation of glucose metabolism
regulation of lipid metabolism
|
|
gptkbp:gene
|
gptkb:NR1H3
|
|
gptkbp:HGNC_ID
|
7961
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LXR-alpha
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p11.2
|
|
gptkbp:molecularWeight
|
~50 kDa
|
|
gptkbp:OMIM
|
602423
|
|
gptkbp:PDB
|
gptkb:1UHL
|
|
gptkbp:regulates
|
gptkb:ABCA1
gptkb:CYP7A1
gptkb:SREBP-1c
lipogenesis
bile acid synthesis
cholesterol efflux
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:UniProtID
|
Q13133
|
|
gptkbp:bfsParent
|
gptkb:NR1H3
|
|
gptkbp:bfsLayer
|
7
|