|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:familial_hypercholesterolemia
|
|
gptkbp:binds
|
gptkb:apolipoprotein_B-100
gptkb:apolipoprotein_E
|
|
gptkbp:biologicalProcess
|
cholesterol homeostasis
lipid transport
lipoprotein receptor activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:degradedBy
|
gptkb:lysosome
|
|
gptkbp:discoveredBy
|
gptkb:Michael_S._Brown
gptkb:Joseph_L._Goldstein
|
|
gptkbp:domain
|
transmembrane domain
EGF-precursor homology domain
O-linked sugar domain
cytoplasmic domain
ligand-binding domain
|
|
gptkbp:encodedBy
|
gptkb:LDLR_gene
|
|
gptkbp:expressedIn
|
gptkb:adrenal_gland
liver
peripheral tissues
|
|
gptkbp:foundIn
|
gptkb:cell_membrane
|
|
gptkbp:function
|
mediates endocytosis of cholesterol-rich LDL
|
|
gptkbp:HGNC_ID
|
6547
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LDL receptor protein
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
|
|
gptkbp:molecularWeight
|
~160 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:familial_hypercholesterolemia
|
|
gptkbp:OMIM
|
606945
|
|
gptkbp:orthologIn
|
gptkb:Dragon
gptkb:dog
gptkb:entomologist
gptkb:lion
gptkb:livestock
gptkb:meat
gptkb:mouse
gptkb:zebrafish
gptkb:yeast
right
|
|
gptkbp:PDB
|
gptkb:1N7D
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:recycledBy
|
gptkb:endosome
|
|
gptkbp:regulates
|
gptkb:SREBP_pathway
cholesterol levels
|
|
gptkbp:relatedTo
|
gptkb:cardiovascular_disease
atherosclerosis
|
|
gptkbp:removesFromBlood
|
gptkb:low-density_lipoprotein_(LDL)
|
|
gptkbp:significance
|
target for statin therapy
|
|
gptkbp:UniProtID
|
gptkb:P01130
|
|
gptkbp:bfsParent
|
gptkb:LDLR
|
|
gptkbp:bfsLayer
|
7
|