low-density lipoprotein (LDL)

URI: https://gptkb.org/entity/low-density_lipoprotein_(LDL)

GPTKB entity

Statements (53)

Predicate	Object
gptkbp:instanceOf	lipoprotein
gptkbp:abbreviation	gptkb:LDL
gptkbp:alsoKnownAs	bad cholesterol
gptkbp:associatedWith	atherosclerosis coronary artery disease
gptkbp:color	yellowish
gptkbp:component	blood plasma
gptkbp:contains	gptkb:apolipoprotein_B-100 cholesterol phospholipids triglycerides
gptkbp:decreasedIn	gptkb:liver_disease hyperthyroidism plant sterols malabsorption fiber intake
gptkbp:density	1.019–1.063 g/mL
gptkbp:discoveredBy	gptkb:John_Gofman
gptkbp:firstDescribed	1950
gptkbp:function	transports cholesterol to tissues
gptkbp:highLevelRisk	increased risk of heart disease
https://www.w3.org/2000/01/rdf-schema#label	low-density lipoprotein (LDL)
gptkbp:improves	gptkb:familial_hypercholesterolemia hypothyroidism nephrotic syndrome saturated fat intake trans fat intake
gptkbp:loweredBy	exercise statins dietary changes
gptkbp:mainLipid	cholesteryl ester
gptkbp:mainProtein	gptkb:apolipoprotein_B-100
gptkbp:measures	blood test
gptkbp:originatedIn	very-low-density lipoprotein (VLDL)
gptkbp:range	less than 100 mg/dL
gptkbp:recipient	gptkb:LDL_receptor
gptkbp:relatedTo	gptkb:high-density_lipoprotein_(HDL) gptkb:intermediate-density_lipoprotein_(IDL) very-low-density lipoprotein (VLDL)
gptkbp:role	cholesterol homeostasis
gptkbp:significance	marker for cardiovascular risk
gptkbp:size	18–25 nm diameter
gptkbp:structure	single apolipoprotein B-100 molecule per particle
gptkbp:studiedIn	gptkb:Framingham_Heart_Study
gptkbp:target	gptkb:PCSK9_inhibitors gptkb:ezetimibe bile acid sequestrants
gptkbp:type	beta-lipoprotein
gptkbp:bfsParent	gptkb:LDL_apheresis gptkb:LDL_receptor_pathway gptkb:High-density_lipoprotein_(HDL) gptkb:Very-low-density_lipoprotein_(VLDL)
gptkbp:bfsLayer	7