Statements (21)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
low cellular cholesterol
|
| gptkbp:discoveredBy |
1990s
|
| gptkbp:dysregulationAssociatedWith |
gptkb:non-alcoholic_fatty_liver_disease
gptkb:metabolic_syndrome atherosclerosis |
| https://www.w3.org/2000/01/rdf-schema#label |
SREBP pathway
|
| gptkbp:involves |
gptkb:endoplasmic_reticulum
gptkb:SCAP gptkb:Golgi_apparatus INSIG SREBP SREBP cleavage SREBP translocation to nucleus |
| gptkbp:occurredIn |
eukaryotic cells
|
| gptkbp:regulates |
lipid metabolism
cholesterol biosynthesis fatty acid synthesis |
| gptkbp:result |
transcriptional activation of lipid biosynthetic genes
|
| gptkbp:bfsParent |
gptkb:LDLR_gene
|
| gptkbp:bfsLayer |
7
|