|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:LDH-A
gptkb:muscle-type_LDH
|
|
gptkbp:associatedWith
|
glycogen storage disease XI
|
|
gptkbp:biologicalProcess
|
oxidoreductase activity
|
|
gptkbp:catalyzes
|
conversion of pyruvate to lactate
|
|
gptkbp:cofactor
|
gptkb:NADH
NAD+
|
|
gptkbp:EC_number
|
1.1.1.27
|
|
gptkbp:encodedBy
|
gptkb:LDHA_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000134333
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
gptkb:testis
liver
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:gene
|
gptkb:LDHA
|
|
gptkbp:GO_term
|
gptkb:GO:0004459
GO:0006096
|
|
gptkbp:HGNC_ID
|
6541
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Lactate dehydrogenase A
|
|
gptkbp:inhibitedBy
|
gptkb:oxamate
gossypol
|
|
gptkbp:involves
|
glycolysis
anaerobic metabolism
|
|
gptkbp:locatedOnChromosome
|
chromosome 11p15.4
|
|
gptkbp:mutationAssociatedWith
|
gptkb:LDHA_deficiency
|
|
gptkbp:OMIM
|
150000
|
|
gptkbp:orthologIn
|
mouse LDHA
rat LDHA
zebrafish LDHA
|
|
gptkbp:pathway
|
gptkb:Warburg_effect
carbohydrate metabolism
|
|
gptkbp:PDB
|
1I10
|
|
gptkbp:product
|
lactate
|
|
gptkbp:proteinFamily
|
gptkb:lactate/malate_dehydrogenase_family
|
|
gptkbp:RefSeq
|
NM_005566
|
|
gptkbp:regulates
|
allosteric regulation
transcriptional regulation
|
|
gptkbp:significance
|
elevated in some cancers
marker for tissue damage
|
|
gptkbp:structure
|
tetrameric protein
|
|
gptkbp:substrate
|
gptkb:pyruvate
|
|
gptkbp:subunit
|
lactate dehydrogenase tetramer
|
|
gptkbp:tissue_specificity
|
high in skeletal muscle
low in heart
|
|
gptkbp:UniProtID
|
gptkb:P00338
|
|
gptkbp:bfsParent
|
gptkb:LDH-A
|
|
gptkbp:bfsLayer
|
7
|