lactic acid dehydrogenase

URI: https://gptkb.org/entity/lactic_acid_dehydrogenase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:catalyzes	conversion of lactate to pyruvate conversion of pyruvate to lactate
gptkbp:clinical_marker_for	gptkb:cancer gptkb:liver_disease myocardial infarction tissue damage hemolysis
gptkbp:cofactor	gptkb:NADH NAD+
gptkbp:discoveredBy	gptkb:Otto_Warburg
gptkbp:EC_number	1.1.1.27
gptkbp:foundIn	gptkb:skeletal_muscle gptkb:kidney heart liver red blood cells
gptkbp:gene	gptkb:LDHA gptkb:LDHB gptkb:LDHC gptkb:LDHD LDHAL6A LDHAL6B
gptkbp:hasIsoform	gptkb:LDH-A gptkb:LDH-B gptkb:LDH-C gptkb:LDH-D gptkb:LDH-E
https://www.w3.org/2000/01/rdf-schema#label	lactic acid dehydrogenase
gptkbp:inhibitedBy	gptkb:oxamate gossypol
gptkbp:molecularWeight	~140 kDa
gptkbp:PDB	1I10 1LTH
gptkbp:presentIn	prokaryotes eukaryotes
gptkbp:product	gptkb:pyruvate gptkb:NADH lactate NAD+
gptkbp:structure	tetramer
gptkbp:substrate	gptkb:pyruvate lactate
gptkbp:UniProtID	gptkb:P00338_(human_LDHA) P07195 (human LDHB)
gptkbp:used_in	gptkb:anaerobic_glycolysis lactic acid fermentation
gptkbp:bfsParent	gptkb:LDH
gptkbp:bfsLayer	6