Kirsten rat sarcoma viral oncogene homolog (KRAS)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:tumor_suppressor gptkb:gene
gptkbp:alias	gptkb:K-Ras gptkb:Ki-Ras gptkb:c-K-ras gptkb:NS_(neuroblastoma_ras_viral_oncogene_homolog)
gptkbp:discoveredBy	gptkb:Harold_E._Varmus gptkb:J._Michael_Bishop
gptkbp:encodes	gptkb:KRAS_protein
gptkbp:Entrez_Gene_ID	3845
gptkbp:expressedIn	many tissues
gptkbp:firstDescribed	1982
gptkbp:function	gptkb:guanine_nucleotide_exchange_factor
gptkbp:geneType	protein-coding
gptkbp:hasTranscriptVariant	gptkb:KRAS4A gptkb:KRAS4B
gptkbp:HGNC_ID	gptkb:HGNC:6407
gptkbp:involvedIn	apoptosis cell differentiation cell proliferation cell signaling
gptkbp:length	6 exons 188 amino acids (KRAS4A) 189 amino acids (KRAS4B)
gptkbp:locatedOnChromosome	gptkb:chromosome_12
gptkbp:mutationAssociatedWith	gptkb:cancer colorectal cancer pancreatic cancer codon 12 codon 13 codon 61 other cancers
gptkbp:OMIM	190070
gptkbp:orthologIn	gptkb:mouse gptkb:right gptkb:zebrafish
gptkbp:proteinFamily	gptkb:RAS_family
gptkbp:regulates	gptkb:MAPK/ERK_pathway gptkb:PI3K/AKT_pathway
gptkbp:relatedTo	gptkb:HRAS gptkb:NRAS
gptkbp:subcellularLocation	gptkb:cytoplasm gptkb:plasma_membrane endomembrane system
gptkbp:target	gptkb:adagrasib gptkb:sotorasib KRAS inhibitors
gptkbp:UniProtID	gptkb:P01116
gptkbp:bfsParent	gptkb:Werner_Kirsten
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	Kirsten rat sarcoma viral oncogene homolog (KRAS)