Kaposi's sarcoma-associated herpesvirus

URI: https://gptkb.org/entity/Kaposi's_sarcoma-associated_herpesvirus

GPTKB entity

Statements (52)

Predicate	Object
gptkbp:instanceOf	gptkb:virus
gptkbp:abbreviation	gptkb:HHV-8
gptkbp:alsoKnownAs	gptkb:KSHV gptkb:human_herpesvirus_8
gptkbp:associatedWith	gptkb:HIV/AIDS immunocompromised individuals
gptkbp:Baltimore_classification	Group I (dsDNA viruses)
gptkbp:cause	gptkb:Kaposi's_sarcoma gptkb:multicentric_Castleman's_disease gptkb:primary_effusion_lymphoma
gptkbp:discoveredBy	gptkb:Patrick_S._Moore gptkb:Yuan_Chang
gptkbp:discoveredIn	1994
gptkbp:encodes	gptkb:Kaposins gptkb:latency-associated_nuclear_antigen_(LANA) gptkb:viral_G_protein-coupled_receptor_(vGPCR) gptkb:viral_interleukin-6_(vIL-6)
gptkbp:enveloped	true
gptkbp:family	gptkb:Herpesviridae
gptkbp:firstIsolatedFrom	gptkb:Kaposi's_sarcoma_lesions
gptkbp:genomeSize	approximately 165 kilobases
gptkbp:genomeType	double-stranded DNA
gptkbp:genus	gptkb:Rhadinovirus
gptkbp:hostedBy	humans
https://www.w3.org/2000/01/rdf-schema#label	Kaposi's sarcoma-associated herpesvirus
gptkbp:latency	establishes latency in B cells
gptkbp:notableFor	gptkb:K15_protein gptkb:K1_protein gptkb:vFLIP gptkb:ORF50_(RTA) gptkb:ORF73_(LANA) gptkb:vCyclin gptkb:vIRF
gptkbp:oncogenic	true
gptkbp:order	gptkb:Herpesvirales
gptkbp:prevalence	higher in Mediterranean region higher in men who have sex with men higher in sub-Saharan Africa
gptkbp:relatedTo	gptkb:Epstein-Barr_virus
gptkbp:replicationSite	gptkb:nucleus
gptkbp:subfamily	gptkb:Gammaherpesvirinae
gptkbp:taxonRank	201850002
gptkbp:transmission	organ transplantation blood transfusion sexual contact saliva
gptkbp:treatment	antiviral drugs (limited efficacy) chemotherapy for associated cancers
gptkbp:vaccineAvailable	false
gptkbp:bfsParent	gptkb:virus gptkb:Herpesviridae
gptkbp:bfsLayer	5