Statements (109)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:virus
|
| gptkbp:associated_with |
gptkb:multicentric_Castleman_disease
gptkb:primary_effusion_lymphoma gptkb:chronic_fatigue_syndrome gptkb:anemia gptkb:HIV/_AIDS fatigue metabolic disorders psychological disorders weight loss autoimmune diseases fever neurological symptoms night sweats chronic inflammation thrombocytopenia immunosuppression gastrointestinal complications endocrine disorders lymphadenopathy HIV infection immune evasion neurocognitive disorders pulmonary complications respiratory symptoms lymphoproliferative disorders cardiovascular complications oral lesions dermatological manifestations viral latency renal complications Kaposi's sarcoma lesions chronic pain syndromes elevated HHV-8 viral load elevated IL-6 levels elevated VEGF levels hypergammaglobulinemia immunological abnormalities increased risk of secondary infections musculoskeletal symptoms serous effusions |
| gptkbp:belongs_to |
Herpesviridae family
|
| gptkbp:cause |
gptkb:multicentric_Castleman_disease
gptkb:primary_effusion_lymphoma gptkb:Kaposi's_sarcoma |
| gptkbp:clinical_trial |
ongoing research studies
|
| gptkbp:community_health |
global health issue
associated with AIDS-related cancers |
| gptkbp:diagnosis |
biopsy
serological tests PCR testing |
| gptkbp:discovered_by |
gptkb:1994
|
| gptkbp:diseases |
gptkb:B_lymphocytes
B cells endothelial cells monocytes |
| gptkbp:epidemiology |
endemic in certain regions
more common in immunocompromised individuals more common in men than women prevalence varies by population |
| gptkbp:family |
gptkb:Herpesviridae
|
| gptkbp:genome_structure |
linear DNA
|
| gptkbp:genus |
gptkb:Rhadinovirus
|
| https://www.w3.org/2000/01/rdf-schema#label |
human herpesvirus 8
|
| gptkbp:is_recognized_as |
HIV-positive individuals
|
| gptkbp:is_vulnerable_to |
no approved vaccine
|
| gptkbp:known_as |
gptkb:KSHV
|
| gptkbp:nutritional_value |
gptkb:LANA-1
v GPCR v IL-6 K8.1 |
| gptkbp:originated_in |
B cells
endothelial cells monocytes |
| gptkbp:prevalence |
higher in certain geographic regions
|
| gptkbp:prevention |
safe sex practices
screening blood donors |
| gptkbp:propagation_method |
organ transplantation
sexual contact blood transfusion |
| gptkbp:replaces |
Kaposi's sarcoma patient
|
| gptkbp:research_focus |
immune response
cancer biology viral pathogenesis cancer virology |
| gptkbp:seed_dispersal |
double-stranded DNA
approximately 165 kb |
| gptkbp:subfamily |
gptkb:Gammaherpesvirinae
|
| gptkbp:symptoms |
weight loss
fever night sweats lymphadenopathy asymptomatic in many cases asymptomatic infection |
| gptkbp:transmission |
organ transplantation
sexual contact blood transfusion |
| gptkbp:treatment |
gptkb:immunotherapy
supportive care radiation therapy chemotherapy antiviral therapy |
| gptkbp:viral_protein |
LANA
v Bcl-2 v GPCR v IL-6 |
| gptkbp:bfsParent |
gptkb:Kaposi's_sarcoma
gptkb:castle |
| gptkbp:bfsLayer |
4
|