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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:LANA-1
KSHV LANA
|
|
gptkbp:binds
|
host chromatin
viral terminal repeat DNA
|
|
gptkbp:discoveredBy
|
1997
|
|
gptkbp:encodedBy
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gptkb:Kaposi's_sarcoma-associated_herpesvirus
|
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gptkbp:fullName
|
Latency-associated nuclear antigen
|
|
gptkbp:function
|
transcriptional regulation
inhibition of p53
maintenance of viral episomes
inhibition of Rb
|
|
gptkbp:gene
|
ORF73
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ORF73 (LANA)
|
|
gptkbp:interactsWith
|
gptkb:Rb_protein
gptkb:CBP/p300
gptkb:p53
gptkb:DNMT3A
BRD4
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
222 kDa
|
|
gptkbp:motif
|
coiled-coil domain
proline-rich region
acidic domain
nuclear localization signal
DNA binding domain
C-terminal repeat region
chromatin binding domain
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:regulates
|
apoptosis
cell cycle
immune evasion
viral latency
host gene expression
|
|
gptkbp:requires
|
KSHV episome persistence
KSHV latency
KSHV tumorigenesis
|
|
gptkbp:role
|
gptkb:Kaposi's_sarcoma
gptkb:multicentric_Castleman's_disease
gptkb:primary_effusion_lymphoma
|
|
gptkbp:subcellularLocation
|
nuclear speckles
PML nuclear bodies
|
|
gptkbp:virus
|
gptkb:Human_herpesvirus_8
|
|
gptkbp:bfsParent
|
gptkb:Kaposi's_sarcoma-associated_herpesvirus
|
|
gptkbp:bfsLayer
|
6
|