latency-associated nuclear antigen (LANA)
GPTKB entity
Statements (25)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
ORF73 protein
|
| gptkbp:associatedWith |
gptkb:Kaposi's_sarcoma
gptkb:multicentric_Castleman's_disease gptkb:primary_effusion_lymphoma |
| gptkbp:detects |
immunofluorescence
|
| gptkbp:encodedBy |
Kaposi's sarcoma-associated herpesvirus (KSHV)
|
| gptkbp:firstDescribed |
1997
|
| gptkbp:function |
maintenance of viral episomes
regulation of viral latency |
| https://www.w3.org/2000/01/rdf-schema#label |
latency-associated nuclear antigen (LANA)
|
| gptkbp:interactsWith |
gptkb:Rb_protein
gptkb:p53 host chromatin |
| gptkbp:locale |
gptkb:nucleus
|
| gptkbp:locatedOnChromosome |
KSHV ORF73
|
| gptkbp:molecularWeight |
~222 kDa
|
| gptkbp:presentIn |
latently infected cells
|
| gptkbp:role |
immune evasion
oncogenesis |
| gptkbp:structure |
contains C-terminal DNA binding domain
contains N-terminal chromatin binding domain |
| gptkbp:usedAs |
marker for KSHV infection
|
| gptkbp:bfsParent |
gptkb:Kaposi's_sarcoma-associated_herpesvirus
|
| gptkbp:bfsLayer |
6
|