|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
Ether-à-go-go-related gene
HERG
|
|
gptkbp:associatedWith
|
sudden cardiac death
Long QT syndrome type 2
drug-induced long QT syndrome
|
|
gptkbp:biologicalProcess
|
cardiac muscle contraction
voltage-gated potassium channel activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gptkb:Mark_Keating
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
hERG potassium channel
|
|
gptkbp:Entrez_Gene_ID
|
3757
ENSG00000055118
|
|
gptkbp:expressedIn
|
heart
|
|
gptkbp:function
|
regulates cardiac action potential repolarization
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6251
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KCNH2
|
|
gptkbp:inhibitedBy
|
gptkb:pentamidine
gptkb:methadone
gptkb:ondansetron
gptkb:azithromycin
gptkb:delavirdine
gptkb:dolutegravir
gptkb:efavirenz
gptkb:elvitegravir
gptkb:etravirine
gptkb:nevirapine
gptkb:raltegravir
gptkb:rilpivirine
gptkb:voriconazole
gptkb:lopinavir
gptkb:arsenic_trioxide
gptkb:cobicistat
gptkb:fluconazole
gptkb:clarithromycin
gptkb:pimozide
gptkb:ritonavir
gptkb:tamoxifen
gptkb:erythromycin
gptkb:ketoconazole
gptkb:tacrolimus
gptkb:atazanavir
gptkb:cisapride
gptkb:tipranavir
gptkb:fluoxetine
gptkb:haloperidol
gptkb:moxifloxacin
gptkb:levofloxacin
gptkb:nelfinavir
gptkb:sertindole
gptkb:telithromycin
gptkb:thioridazine
quinidine
amiodarone
indinavir
itraconazole
posaconazole
saquinavir
chloroquine
maraviroc
toremifene
ziprasidone
astemizole
dofetilide
droperidol
fosamprenavir
gatifloxacin
gemifloxacin
grepafloxacin
ibutilide
levomethadyl
mesoridazine
ranolazine
sotalol
sparfloxacin
terfenadine
|
|
gptkbp:length
|
1159 amino acids
|
|
gptkbp:locatedOnChromosome
|
7q36.1
|
|
gptkbp:mutationAssociatedWith
|
gptkb:arrhythmia
|
|
gptkbp:OMIM
|
152427
|
|
gptkbp:orthologInMouse
|
gptkb:Kcnh2
|
|
gptkbp:product
|
Potassium voltage-gated channel subfamily H member 2
|
|
gptkbp:proteinFamily
|
potassium channel
|
|
gptkbp:UniProtID
|
gptkb:Q12809
|
|
gptkbp:bfsParent
|
gptkb:long_QT_syndrome
|
|
gptkbp:bfsLayer
|
6
|