|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Ether-a-go-go-related_gene_protein
gptkb:hERG
|
|
gptkbp:associatedWith
|
gptkb:Long_QT_syndrome_2
gptkb:Short_QT_syndrome_1
gptkb:Ventricular_fibrillation
|
|
gptkbp:component
|
integral component of plasma membrane
|
|
gptkbp:encodedBy
|
gptkb:KCNH2_gene
|
|
gptkbp:function
|
gptkb:voltage-gated_potassium_channel
involved in cardiac action potential repolarization
potassium ion transmembrane transport
|
|
gptkbp:GOProcess
|
cardiac muscle cell action potential
|
|
gptkbp:hasGeneName
|
gptkb:KCNH2
|
|
gptkbp:hasIonChannelActivity
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
O60500
|
|
gptkbp:inhibitionLeadsTo
|
QT interval prolongation
|
|
gptkbp:length
|
1159 amino acids
|
|
gptkbp:locatedOnChromosome
|
7q36.1
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
127 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Kcnh2
|
|
gptkbp:PDB
|
gptkb:5VA1
gptkb:5VA2
gptkb:6UZZ
gptkb:6V01
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:subunit
|
homotetramer
|
|
gptkbp:targetOfDrug
|
antipsychotic drugs
antihistamines
antiarrhythmic drugs
|
|
gptkbp:tissue_specificity
|
brain
heart
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
gptkb:O60500
|
|
gptkbp:bfsParent
|
gptkb:NTRN
|
|
gptkbp:bfsLayer
|
6
|