Interleukin-7 receptor subunit alpha

URI: https://gptkb.org/entity/Interleukin-7_receptor_subunit_alpha
GPTKB entity
Statements (39)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:CD127
gptkbp:associatedWith multiple sclerosis
immunodeficiency
gptkbp:binds interleukin-7
thymic stromal lymphopoietin
gptkbp:component gptkb:interleukin-7_receptor
thymic stromal lymphopoietin receptor
gptkbp:discoveredBy early 1990s
gptkbp:Entrez_Gene_ID 3575
ENSG00000168685
gptkbp:expressedIn gptkb:B_cells
gptkb:T_cells
hematopoietic progenitor cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function immune system development
lymphocyte homeostasis
cytokine receptor activity
gptkbp:gene IL7R
gptkbp:GO_term GO:0004896
GO:0042102
gptkbp:HGNC_ID 6010
https://www.w3.org/2000/01/rdf-schema#label Interleukin-7 receptor subunit alpha
gptkbp:interactsWith gptkb:JAK1
gptkb:JAK3
interleukin-2 receptor gamma chain
gptkbp:locatedOnChromosome chromosome 5q31.1
gptkbp:location gptkb:cell_membrane
gptkbp:molecularWeight 45-60 kDa
gptkbp:mutationAssociatedWith immunodeficiency
gptkbp:OMIM 146661
gptkbp:PDB 3DI2
gptkbp:postTranslationalModification glycosylation
gptkbp:signal_transduction_pathway gptkb:JAK-STAT_pathway
gptkbp:structure single-pass type I membrane protein
gptkbp:UniProtID P16871
gptkbp:bfsParent gptkb:CD127
gptkb:IL7R_gene
gptkbp:bfsLayer 8