|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
CD41A
GPIIb
integrin alpha-IIb subunit
|
|
gptkbp:associatedWith
|
gptkb:Glanzmann_thrombasthenia
|
|
gptkbp:biologicalProcess
|
blood coagulation
hemostasis
cell adhesion
|
|
gptkbp:clinicalTrialPhase
|
platelet aggregation assay
|
|
gptkbp:cytoplasmicDomain
|
present
|
|
gptkbp:discoveredBy
|
gptkb:Edward_J._Benz_Jr.
|
|
gptkbp:encodes
|
Integrin alpha-IIb
|
|
gptkbp:Entrez_Gene_ID
|
3674
ENSG00000185245
|
|
gptkbp:expressedIn
|
gptkb:megakaryocytes
platelets
|
|
gptkbp:extracellularDomain
|
present
|
|
gptkbp:formsComplexWith
|
ITGB3
|
|
gptkbp:function
|
platelet aggregation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
6157
|
|
gptkbp:interactsWith
|
gptkb:fibrinogen
gptkb:von_Willebrand_factor
gptkb:fibronectin
vitronectin
thrombospondin
|
|
gptkbp:locatedOnChromosome
|
17q21.32
|
|
gptkbp:mutationAssociatedWith
|
gptkb:ClinVar
gptkb:HGMD
gptkb:LOVD
gptkb:bleeding_disorder
|
|
gptkbp:OMIM
|
607759
|
|
gptkbp:orthologInMouse
|
Itga2b
|
|
gptkbp:pathway
|
gptkb:ECM-receptor_interaction
focal adhesion
platelet activation
integrin signaling pathway
|
|
gptkbp:product
|
gptkb:CD41
heterodimer with ITGB3
|
|
gptkbp:proteinFamily
|
integrin alpha chain family
|
|
gptkbp:significance
|
diagnosis of Glanzmann thrombasthenia
target for antiplatelet therapy
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:subcellularLocation
|
gptkb:plasma_membrane
|
|
gptkbp:transmembraneDomains
|
present
|
|
gptkbp:UniProtID
|
P08514
|
|
gptkbp:bfsParent
|
gptkb:GATA1
gptkb:CD41
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ITGA2B
|