|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Factor_VIII-related_antigen
gptkb:VWF
|
|
gptkbp:associatedWith
|
gptkb:von_Willebrand_disease
|
|
gptkbp:binds
|
gptkb:platelet_glycoprotein_Ib
collagen
factor VIII
|
|
gptkbp:clinicalTrialPhase
|
VWF antigen assay
ristocetin cofactor activity
|
|
gptkbp:deficiencyCauses
|
bleeding tendency
|
|
gptkbp:discoveredBy
|
gptkb:Erik_Adolf_von_Willebrand
|
|
gptkbp:encodedBy
|
gptkb:VWF_gene
|
|
gptkbp:foundIn
|
blood plasma
|
|
gptkbp:function
|
binds to factor VIII
mediates platelet adhesion
|
|
gptkbp:halfLife
|
8-12 hours
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
von Willebrand factor
|
|
gptkbp:locatedOnChromosome
|
12p13.3
|
|
gptkbp:location
|
gptkb:megakaryocytes
endothelial cells
|
|
gptkbp:molecularWeight
|
~270 kDa (monomer)
|
|
gptkbp:releasedFromPrison
|
gptkb:Weibel-Palade_bodies
alpha granules of platelets
|
|
gptkbp:role
|
hemostasis
|
|
gptkbp:structure
|
multimeric protein
|
|
gptkbp:bfsParent
|
gptkb:CD42b
gptkb:CD61
gptkb:Palade_bodies
gptkb:Glycoprotein_IIb/IIIa
gptkb:Primary_hemostasis
|
|
gptkbp:bfsLayer
|
6
|