|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:approvedBy
|
metastatic melanoma
metastatic renal cell carcinoma
|
|
gptkbp:clinicalTrialPhase
|
immunotherapy for cancer
|
|
gptkbp:discoveredBy
|
K. Takatsuki
Tada Tasuku
|
|
gptkbp:discoveredIn
|
1976
|
|
gptkbp:expressedIn
|
lymphoid tissue
|
|
gptkbp:fullName
|
Interleukin 2
|
|
gptkbp:function
|
regulates immune response
activates natural killer cells
promotes proliferation of B cells
stimulates growth and differentiation of T cells
|
|
gptkbp:gene
|
gptkb:IL2
|
|
gptkbp:GOID
|
gptkb:GO:0005134
|
|
gptkbp:HGNC_ID
|
6001
|
|
gptkbp:homology
|
member of the common gamma chain cytokine family
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL 2
|
|
gptkbp:inhibitedBy
|
gptkb:cyclosporine
gptkb:tacrolimus
gptkb:glucocorticoids
|
|
gptkbp:length
|
153
|
|
gptkbp:locatedOnChromosome
|
gptkb:4q27
|
|
gptkbp:molecularWeight
|
17.6 kDa
|
|
gptkbp:OMIM
|
147680
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1M47
|
|
gptkbp:producedBy
|
activated T cells
|
|
gptkbp:promotion
|
gptkb:IL-1
gptkb:IL-6
immune response
mitogen
|
|
gptkbp:receptorSubunits
|
alpha (CD25)
beta (CD122)
gamma (CD132)
|
|
gptkbp:recipient
|
gptkb:IL-2_receptor
|
|
gptkbp:regulates
|
gptkb:regulatory_T_cells
immune tolerance
effector T cells
|
|
gptkbp:sideEffect
|
gptkb:capillary_leak_syndrome
fever
fatigue
chills
hypotension
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
four alpha-helix bundle
|
|
gptkbp:UniProtID
|
gptkb:P60568
|
|
gptkbp:usedAsDrug
|
gptkb:aldesleukin
|
|
gptkbp:bfsParent
|
gptkb:Illinois_Route_2
|
|
gptkbp:bfsLayer
|
7
|