Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
cytokine |
| gptkbp:alternativeName |
Interleukin-1 alpha
|
| gptkbp:associatedWith |
gptkb:cancer
atherosclerosis sepsis autoimmune diseases rheumatoid arthritis |
| gptkbp:cleavage |
gptkb:calpain
|
| gptkbp:discoveredBy |
Charles A. Dinarello
|
| gptkbp:discoveredIn |
1974
|
| gptkbp:encodedBy |
IL1A gene
|
| gptkbp:Entrez_Gene_ID |
3552
|
| gptkbp:expressedIn |
macrophages
endothelial cells monocytes epithelial cells |
| gptkbp:foundIn |
humans
mammals |
| gptkbp:function |
regulates apoptosis
regulates cell proliferation induces fever pro-inflammatory mediator stimulates acute phase response |
| gptkbp:HGNC_ID |
5991
|
| https://www.w3.org/2000/01/rdf-schema#label |
IL-1α
|
| gptkbp:inhibitedBy |
gptkb:IL-1_receptor_antagonist
gptkb:anakinra |
| gptkbp:involvedIn |
immune response
inflammatory response |
| gptkbp:length |
159 amino acids (mature form)
271 amino acids (precursor) |
| gptkbp:locatedOnChromosome |
2q14
|
| gptkbp:memberOf |
interleukin-1 family
|
| gptkbp:molecularWeight |
17 kDa (mature form)
31 kDa (precursor) |
| gptkbp:OMIM |
147760
|
| gptkbp:PDB |
1ITB
|
| gptkbp:postTranslationalModification |
phosphorylation
myristoylation |
| gptkbp:predecessor |
pro-IL-1α
|
| gptkbp:promotion |
gptkb:matrix_metalloproteinases
production of chemokines expression of adhesion molecules production of other cytokines |
| gptkbp:recipient |
IL-1 receptor type I
IL-1 receptor type II |
| gptkbp:structure |
single polypeptide chain
|
| gptkbp:UniProtID |
P01583
|
| gptkbp:bfsParent |
gptkb:IL-1
|
| gptkbp:bfsLayer |
7
|