Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
protein receptor
|
| gptkbp:binds |
gptkb:insulin-like_growth_factor_2
gptkb:insulin-like_growth_factor_1 |
| gptkbp:domain |
tyrosine kinase domain
|
| gptkbp:encodedBy |
gptkb:IGF1R_gene
|
| gptkbp:expressedIn |
many tissues
|
| gptkbp:formsComplexWith |
gptkb:insulin_receptor
|
| gptkbp:foundIn |
gptkb:cell_membrane
|
| gptkbp:function |
mediates cell differentiation
mediates cell growth mediates cell survival mediates cell proliferation |
| https://www.w3.org/2000/01/rdf-schema#label |
IGF receptor
|
| gptkbp:involvedIn |
gptkb:MAPK_pathway
gptkb:PI3K-Akt_pathway signal transduction |
| gptkbp:relatedTo |
gptkb:insulin_receptor
|
| gptkbp:significance |
gptkb:cancer
gptkb:diabetes growth disorders |
| gptkbp:subunit |
alpha subunit
beta subunit |
| gptkbp:target |
cancer therapies
monoclonal antibodies tyrosine kinase inhibitors |
| gptkbp:bfsParent |
gptkb:Insulin-like_Growth_Factor
|
| gptkbp:bfsLayer |
7
|