|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:acute_myeloid_leukemia
glioma
metabolic disorders
|
|
gptkbp:cofactor
|
NADP+
|
|
gptkbp:encodes
|
isocitrate dehydrogenase [NADP] mitochondrial enzyme
|
|
gptkbp:Entrez_Gene_ID
|
3418
ENSG00000182054
|
|
gptkbp:enzymeCommissionNumber
|
1.1.1.42
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
heart
liver
|
|
gptkbp:fullName
|
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
|
|
gptkbp:function
|
catalyzes oxidative decarboxylation of isocitrate to alpha-ketoglutarate
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
5383
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IDH2
|
|
gptkbp:inhibitedBy
|
gptkb:enasidenib
AG-221
|
|
gptkbp:locatedOnChromosome
|
gptkb:15q26.1
|
|
gptkbp:mutationAssociatedWith
|
production of 2-hydroxyglutarate
R140Q
R172K
|
|
gptkbp:OMIM
|
147650
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Idh2
|
|
gptkbp:orthologInYeast
|
IDP2
|
|
gptkbp:pathway
|
tricarboxylic acid cycle
glutamine metabolism
|
|
gptkbp:RefSeq
|
NM_002168
|
|
gptkbp:subcellularLocation
|
mitochondrion
|
|
gptkbp:UniProtID
|
P48735
|
|
gptkbp:bfsParent
|
gptkb:isocitrate_dehydrogenase
|
|
gptkbp:bfsLayer
|
6
|