Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:catalyzes |
oxidative decarboxylation of isocitrate to alpha-ketoglutarate
|
| gptkbp:cofactor |
NADP+
NAD+ |
| gptkbp:discoveredBy |
1950s
|
| gptkbp:EC_number |
1.1.1.42
|
| gptkbp:foundIn |
mitochondria
cytosol |
| gptkbp:gene |
gptkb:IDH1
gptkb:IDH2 gptkb:IDH3A gptkb:IDH3B gptkb:IDH3G |
| gptkbp:hasIsoform |
gptkb:IDH1
gptkb:IDH2 gptkb:IDH3 |
| https://www.w3.org/2000/01/rdf-schema#label |
isocitrate dehydrogenase
|
| gptkbp:inhibitedBy |
oxalosuccinate
|
| gptkbp:involves |
cellular respiration
citric acid cycle |
| gptkbp:mutationAssociatedWith |
gptkb:acute_myeloid_leukemia
glioma |
| gptkbp:produces |
gptkb:NADH
CO2 NADPH |
| gptkbp:product |
gptkb:alpha-ketoglutarate
|
| gptkbp:requires |
Mg2+
Mn2+ |
| gptkbp:structure |
homodimer or heterotetramer
|
| gptkbp:substrate |
gptkb:isocitrate
|
| gptkbp:bfsParent |
gptkb:Krebs_cycle
|
| gptkbp:bfsLayer |
5
|