Statements (14)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
mutant
|
| gptkbp:aminoAcidChange |
Arginine to Glutamine
|
| gptkbp:associatedWith |
gptkb:acute_myeloid_leukemia
myelodysplastic syndromes |
| gptkbp:codonPosition |
140
|
| gptkbp:foundIn |
gptkb:human
|
| https://www.w3.org/2000/01/rdf-schema#label |
R140Q (IDH2)
|
| gptkbp:mutationAssociatedWith |
missense
|
| gptkbp:regulates |
gptkb:IDH2
|
| gptkbp:result |
2-hydroxyglutarate accumulation
neomorphic enzyme activity |
| gptkbp:targetOfDrug |
gptkb:enasidenib
|
| gptkbp:bfsParent |
gptkb:IDH1/2_mutation
|
| gptkbp:bfsLayer |
6
|