|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:ADP
Ca2+
|
|
gptkbp:catalyzes
|
oxidative decarboxylation of isocitrate to alpha-ketoglutarate
|
|
gptkbp:cofactor
|
NADP+
NAD+
|
|
gptkbp:discoveredBy
|
1950s
|
|
gptkbp:EC_number
|
1.1.1.42
|
|
gptkbp:foundIn
|
mitochondria
cytosol
|
|
gptkbp:gene
|
gptkb:IDH1
gptkb:IDH2
gptkb:IDH3A
gptkb:IDH3B
gptkb:IDH3G
|
|
gptkbp:hasIsoform
|
gptkb:IDH1
gptkb:IDH2
gptkb:IDH3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Isocitrate dehydrogenase
|
|
gptkbp:inhibitedBy
|
gptkb:ATP
oxalosuccinate
|
|
gptkbp:involves
|
cellular respiration
citric acid cycle
|
|
gptkbp:mutation_produces
|
2-hydroxyglutarate
|
|
gptkbp:mutationAssociatedWith
|
gptkb:R132H_(IDH1)
gptkb:R140Q_(IDH2)
gptkb:R172K_(IDH2)
gptkb:acute_myeloid_leukemia
glioma
|
|
gptkbp:pathway
|
tricarboxylic acid cycle
glutamine metabolism
|
|
gptkbp:presentIn
|
prokaryotes
eukaryotes
|
|
gptkbp:produces
|
gptkb:NADH
CO2
NADPH
|
|
gptkbp:product
|
gptkb:alpha-ketoglutarate
|
|
gptkbp:requires
|
Mg2+
Mn2+
|
|
gptkbp:structure
|
homodimer
heterotetramer
|
|
gptkbp:substrate
|
gptkb:isocitrate
|
|
gptkbp:targetOfDrug
|
gptkb:ivosidenib
gptkb:enasidenib
|
|
gptkbp:UniProtID
|
P48735 (IDH1, human)
P48736 (IDH2, human)
P50213 (IDH3A, human)
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|