Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
IN
|
| gptkbp:compatibleWith |
host cells (prior to infection)
|
| gptkbp:discoveredIn |
1980s
|
| gptkbp:EC_number |
2.7.7.49
|
| gptkbp:encodedBy |
pol gene in retroviruses
|
| gptkbp:foundIn |
retroviruses
|
| gptkbp:function |
catalyzes integration of viral DNA into host genome
|
| https://www.w3.org/2000/01/rdf-schema#label |
integrase
|
| gptkbp:inhibitedBy |
gptkb:dolutegravir
gptkb:elvitegravir gptkb:raltegravir bictegravir |
| gptkbp:mechanismOfAction |
performs 3'-processing and strand transfer
|
| gptkbp:molecularWeight |
~32 kDa (HIV-1 integrase)
|
| gptkbp:presentIn |
gptkb:HIV-1
gptkb:HIV-2 gptkb:HTLV-1 other retroviruses |
| gptkbp:requires |
retroviral replication
|
| gptkbp:structure |
contains C-terminal DNA-binding domain
contains N-terminal zinc-binding domain contains catalytic core domain |
| gptkbp:target |
gptkb:integrase_inhibitors
antiretroviral therapy |
| gptkbp:usedIn |
gene therapy research
|
| gptkbp:bfsParent |
gptkb:HIV
|
| gptkbp:bfsLayer |
5
|