|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:MHC_(human)
|
|
gptkbp:associatedWith
|
gptkb:systemic_lupus_erythematosus
gptkb:myasthenia_gravis
Graves' disease
multiple sclerosis
type 1 diabetes
psoriasis
narcolepsy
rheumatoid arthritis
celiac disease
ankylosing spondylitis
|
|
gptkbp:containsGene
|
gptkb:HLA-A
gptkb:HLA-B
gptkb:HLA-C
gptkb:HLA-DP
gptkb:HLA-DQ
gptkb:HLA-DR
|
|
gptkbp:database
|
gptkb:UniProt:_P01889
Ensembl: ENSG00000206503
NCBI Gene: 3105
|
|
gptkbp:discoveredBy
|
gptkb:Jean_Dausset
|
|
gptkbp:encodes
|
major histocompatibility complex proteins
|
|
gptkbp:expressedIn
|
cell surface
most nucleated cells
|
|
gptkbp:firstDescribed
|
1958
|
|
gptkbp:fullName
|
gptkb:Human_Leukocyte_Antigen_complex
|
|
gptkbp:function
|
regulation of the immune system
|
|
gptkbp:hasPolymorphism
|
high
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HLA complex (human)
|
|
gptkbp:importantFor
|
pharmacogenomics
disease association studies
vaccine response
tissue typing
|
|
gptkbp:length
|
3.6 megabases
|
|
gptkbp:locatedOn
|
gptkb:chromosome_6
|
|
gptkbp:numberOfGenes
|
over 200
|
|
gptkbp:OMIM
|
142800
|
|
gptkbp:orthologIn
|
gptkb:MHC_(mouse)
|
|
gptkbp:parentComplex
|
gptkb:major_histocompatibility_complex
|
|
gptkbp:recognizedBy
|
gptkb:T_cell_receptors
antibodies
|
|
gptkbp:role
|
antigen presentation
organ transplant compatibility
autoimmune disease susceptibility
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:subdivision
|
class I region
class II region
class III region
|
|
gptkbp:bfsParent
|
gptkb:major_histocompatibility_complex_(MHC)
|
|
gptkbp:bfsLayer
|
6
|