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gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
RPD3-2
SMAP45
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
epigenetic regulation
|
|
gptkbp:biologicalProcess
|
chromatin modification
histone deacetylase activity
transcriptional repression
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
researchers in the late 1990s
|
|
gptkbp:encodes
|
gptkb:Histone_deacetylase_3
|
|
gptkbp:Entrez_Gene_ID
|
8841
ENSG00000171720
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1999
|
|
gptkbp:function
|
regulation of transcription
histone deacetylation
|
|
gptkbp:GO_term
|
GO:0004407
|
|
gptkbp:HGNC_ID
|
gptkb:HDAC3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HDAC3 gene
|
|
gptkbp:interactsWith
|
gptkb:HDAC2
gptkb:HDAC1
gptkb:NCoR
gptkb:SMRT
|
|
gptkbp:length
|
~42 kb
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
5q31.3
|
|
gptkbp:mutationAssociatedWith
|
intellectual disability
cancer progression
|
|
gptkbp:numberOfExons
|
15
|
|
gptkbp:OMIM
|
605166
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Hdac3
|
|
gptkbp:proteinFamily
|
gptkb:class_I_HDAC
histone deacetylase family
|
|
gptkbp:RefSeq
|
NM_003883
|
|
gptkbp:regulates
|
apoptosis
DNA repair
gene expression
metabolism
immune response
cell cycle
neuronal function
|
|
gptkbp:significance
|
biomarker for disease
potential drug target
|
|
gptkbp:target
|
HDAC inhibitors
|
|
gptkbp:UniProtID
|
gptkb:O15379
|
|
gptkbp:bfsParent
|
gptkb:HDAC3
|
|
gptkbp:bfsLayer
|
7
|