Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
gptkb:PACE
gptkb:PCSK3 |
| gptkbp:alternativeName |
gptkb:PACE
gptkb:PCSK3 Paired basic Amino acid Cleaving Enzyme |
| gptkbp:associatedWith |
gptkb:cancer
infectious diseases |
| gptkbp:cleavage |
precursor proteins at paired basic residues
|
| gptkbp:discoveredBy |
W. Thomas et al.
|
| gptkbp:discoveredIn |
1990
|
| gptkbp:encodes |
furin protein
|
| gptkbp:Entrez_Gene_ID |
5045
ENSG00000140564 |
| gptkbp:expressedIn |
many tissues
|
| gptkbp:function |
cleavage of precursor proteins
proprotein convertase activity |
| gptkbp:geneType |
protein-coding
|
| gptkbp:HGNC_ID |
HGNC:8568
|
| https://www.w3.org/2000/01/rdf-schema#label |
FURIN gene
|
| gptkbp:involvedIn |
activation of viral glycoproteins
processing of growth factors processing of hormones processing of receptors processing of matrix metalloproteinases |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_15
gptkb:15q26.1 |
| gptkbp:mutationAssociatedWith |
disease susceptibility
|
| gptkbp:OMIM |
136950
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Furin
|
| gptkbp:pathway |
gptkb:TGF-beta_signaling_pathway
gptkb:Notch_signaling_pathway viral entry into host cell protein processing in endoplasmic reticulum insulin processing |
| gptkbp:product |
gptkb:furin
serine endoprotease |
| gptkbp:proteinFamily |
proprotein convertase family
|
| gptkbp:regulates |
regulated by microRNAs
regulated by transcription factors |
| gptkbp:significance |
potential target for cancer therapy
potential target for antiviral therapy |
| gptkbp:subcellularLocation |
gptkb:trans-Golgi_network
gptkb:secretory_vesicles endosomes cell surface |
| gptkbp:UniProtID |
P09958
|
| gptkbp:bfsParent |
gptkb:furin
|
| gptkbp:bfsLayer |
7
|