Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
Furin
Paired basic amino acid cleaving enzyme |
| gptkbp:associatedWith |
gptkb:cancer
infectious diseases cholesterol metabolism |
| gptkbp:cleavage |
precursor proteins at paired basic residues
|
| gptkbp:discoveredBy |
gptkb:Gary_Thomas
|
| gptkbp:discoveredIn |
1990
|
| gptkbp:EC_number |
3.4.21.75
|
| gptkbp:encodes |
Furin
|
| gptkbp:Entrez_Gene_ID |
5045
ENSG00000140564 |
| gptkbp:expressedIn |
brain
liver pancreas |
| gptkbp:function |
proprotein convertase activity
serine endopeptidase activity |
| gptkbp:geneType |
protein-coding
|
| gptkbp:HGNC_ID |
HGNC:8746
|
| https://www.w3.org/2000/01/rdf-schema#label |
PCSK3
|
| gptkbp:involvedIn |
embryonic development
regulation of blood pressure activation of precursor proteins processing of viral glycoproteins |
| gptkbp:length |
794 amino acids
|
| gptkbp:locatedOnChromosome |
gptkb:15q26.1
|
| gptkbp:molecularWeight |
97 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:familial_hypercholesterolemia
diseases of iron metabolism |
| gptkbp:OMIM |
136950
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Pcsk3
|
| gptkbp:proteinFamily |
proprotein convertase family
|
| gptkbp:regulates |
growth factor activation
matrix metalloproteinase activation prohormone processing |
| gptkbp:relatedTo |
PCSK7
PCSK1 PCSK2 PCSK4 PCSK5 PCSK6 |
| gptkbp:subcellularLocation |
gptkb:cell_membrane
gptkb:trans-Golgi_network endosomes |
| gptkbp:target |
antiviral drugs
cancer therapeutics furin inhibitors |
| gptkbp:UniProtID |
P09958
|
| gptkbp:bfsParent |
gptkb:Furin_(gene)
gptkb:FURIN_gene |
| gptkbp:bfsLayer |
8
|