|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:PACE
gptkb:paired_basic_amino_acid_cleaving_enzyme
|
|
gptkbp:associatedWith
|
gptkb:cancer
infectious diseases
cardiovascular diseases
|
|
gptkbp:cleavesAfter
|
Arg-X-(Lys/Arg)-Arg sequence
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodedBy
|
gptkb:FURIN_gene
|
|
gptkbp:Entrez_Gene_ID
|
5045
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.4.21.75
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
serine-type endopeptidase activity
proteolytic processing of precursor proteins
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
furin
|
|
gptkbp:inhibitedBy
|
gptkb:alpha1-antitrypsin_Portland_variant
dec-RVKR-cmk
|
|
gptkbp:involvedIn
|
activation of viral glycoproteins
processing of growth factors
processing of hormones
processing of receptors
|
|
gptkbp:locatedIn
|
gptkb:Golgi_apparatus
|
|
gptkbp:locatedOnChromosome
|
gptkb:15q26.1
|
|
gptkbp:location
|
gptkb:trans-Golgi_network
endosomes
cell surface
|
|
gptkbp:memberOf
|
proprotein convertase family
|
|
gptkbp:molecularWeight
|
~98 kDa
|
|
gptkbp:OMIM
|
136950
|
|
gptkbp:orthologIn
|
gptkb:Gallus_gallus
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:5JXZ
5JXG
5JXR
5JXS
5JXT
5JXU
5JXV
5JXW
5JXX
5JXY
|
|
gptkbp:structure
|
type I transmembrane protein
|
|
gptkbp:substrate
|
gptkb:SARS-CoV-2_spike_protein
gptkb:HIV-1_gp160
gptkb:pro-TGF-beta1
gptkb:pro-VEGF-C
gptkb:pro-beta-nerve_growth_factor
gptkb:proalbumin
gptkb:proparathyroid_hormone
|
|
gptkbp:UniProtID
|
P09958
|
|
gptkbp:bfsParent
|
gptkb:SARS-CoV-2_spike_protein
|
|
gptkbp:bfsLayer
|
6
|