|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:PACE
Paired basic Amino acid Cleaving Enzyme
|
|
gptkbp:associatedWith
|
gptkb:cancer
infectious diseases
|
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gptkbp:cleavage
|
gptkb:SARS-CoV-2_spike_protein
gptkb:pro-beta-nerve_growth_factor
gptkb:proalbumin
gptkb:proparathyroid_hormone
precursor proteins
HIV envelope glycoprotein gp160
pro-membrane type-1 matrix metalloproteinase
|
|
gptkbp:cleavage_site_specificity
|
Arg-X-(Lys/Arg)-Arg' sequence
|
|
gptkbp:discoveredBy
|
Gary Thomas et al.
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodes
|
furin protein
|
|
gptkbp:Entrez_Gene_ID
|
5045
ENSG00000140564
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.4.21.75
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
endopeptidase
|
|
gptkbp:gene
|
gptkb:FURIN
|
|
gptkbp:geneType
|
protein-coding
|
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gptkbp:hasTranscriptVariant
|
multiple
|
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gptkbp:HGNC_ID
|
HGNC:8568
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FURIN
|
|
gptkbp:inhibitedBy
|
gptkb:alpha1-antitrypsin_Portland_variant
decanoyl-RVKR-chloromethylketone
|
|
gptkbp:involves
|
activation of viral glycoproteins
processing of growth factors
processing of receptors
processing of bacterial toxins
|
|
gptkbp:length
|
794
|
|
gptkbp:locatedOnChromosome
|
gptkb:15q26.1
chr15:91,420,000-91,470,000
|
|
gptkbp:member
|
proprotein convertase family
|
|
gptkbp:molecularWeight
|
~90 kDa
|
|
gptkbp:OMIM
|
136950
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Furin
|
|
gptkbp:pathway
|
gptkb:TGF-beta_signaling_pathway
gptkb:Notch_signaling_pathway
viral entry into host cell
protein processing in endoplasmic reticulum
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:trans-Golgi_network
endosomes
|
|
gptkbp:UniProtID
|
P09958
|
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gptkbp:bfsParent
|
gptkb:Furin_(gene)
|
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gptkbp:bfsLayer
|
8
|