|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:associatedWith
|
gptkb:cancer
tumor suppression
|
|
gptkbp:biologicalProcess
|
tumor suppressor
nucleotide hydrolase
|
|
gptkbp:discoveredBy
|
Ohta et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:downregulatedIn
|
many cancers
|
|
gptkbp:encodes
|
Fragile Histidine Triad protein
|
|
gptkbp:Entrez_Gene_ID
|
2272
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
Fragile Histidine Triad
|
|
gptkbp:hasBiologicalActivity
|
apoptosis induction
diadenosine triphosphate hydrolase
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FHIT
|
|
gptkbp:interactsWith
|
gptkb:Mdm2
gptkb:FADD
gptkb:caspase-8
gptkb:p53
gptkb:beta-catenin
ubiquitin
|
|
gptkbp:length
|
10 exons
|
|
gptkbp:locatedOnChromosome
|
3p14.2
chromosome 3p14.2
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
esophageal cancer
pancreatic cancer
translocation
deletion
gastric cancer
renal cell carcinoma
loss of heterozygosity
|
|
gptkbp:OMIM
|
601153
|
|
gptkbp:orthologInC.elegans
|
F26E4.6
|
|
gptkbp:orthologInDrosophila
|
CG6190
|
|
gptkbp:orthologInMouse
|
Fhit
|
|
gptkbp:orthologInYeast
|
HNT3
|
|
gptkbp:proteinFamily
|
histidine triad motif
|
|
gptkbp:regulates
|
apoptosis
cell cycle
DNA damage response
|
|
gptkbp:relatedTo
|
fragile site FRA3B
|
|
gptkbp:UniProtID
|
P49789
|
|
gptkbp:bfsParent
|
gptkb:chromosome_3
|
|
gptkbp:bfsLayer
|
6
|