|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:cAMP
|
|
gptkbp:alternativeName
|
RAPGEF3 protein
cAMP-GEFI
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:depression
gptkb:diabetes
|
|
gptkbp:discoveredBy
|
de Rooij et al.
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:encodedBy
|
gptkb:RAPGEF3
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000111331
11069
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
heart
liver
pancreas
|
|
gptkbp:fullName
|
Exchange protein directly activated by cAMP 1
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:HGNC_ID
|
HGNC:17143
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Epac1
|
|
gptkbp:inhibitedBy
|
gptkb:CE3F4
gptkb:ESI-09
|
|
gptkbp:locatedOnChromosome
|
12q13.11
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~100 kDa
|
|
gptkbp:organism
|
gptkb:human
|
|
gptkbp:orthologIn
|
gptkb:mouse
right
|
|
gptkbp:PDB
|
2BYV
4MGI
|
|
gptkbp:phosphorylates
|
Serine 108
Serine 110
|
|
gptkbp:regulates
|
cell adhesion
cell junction formation
insulin secretion
neuronal signaling
cardiac function
|
|
gptkbp:relatedTo
|
gptkb:Epac2
gptkb:cAMP_signaling_pathway
Rap1 activation
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:structure
|
REM domain
cAMP-binding domain
CDC25-homology domain
|
|
gptkbp:UniProtID
|
O95398
|
|
gptkbp:bfsParent
|
gptkb:Epac
gptkb:EPAC1
|
|
gptkbp:bfsLayer
|
7
|