|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:cAMP
|
|
gptkbp:alternativeName
|
RAPGEF3 protein
cAMP-GEFI
|
|
gptkbp:discoveredBy
|
1998
|
|
gptkbp:domain
|
DEP domain
RA domain
REM domain
Ras-GEF domain
cAMP-binding domain
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000139132
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
heart
pancreas
|
|
gptkbp:fullName
|
Exchange Protein Directly Activated by cAMP 1
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:gene
|
gptkb:RAPGEF3
|
|
gptkbp:HGNC_ID
|
HGNC:16862
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EPAC1
|
|
gptkbp:inhibitedBy
|
gptkb:CE3F4
gptkb:ESI-09
|
|
gptkbp:interactsWith
|
gptkb:Rap1
gptkb:Rap2
|
|
gptkbp:locatedOnChromosome
|
12q13.11
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~100 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Epac1
|
|
gptkbp:pathway
|
gptkb:Rap1_signaling_pathway
gptkb:cAMP_signaling_pathway
|
|
gptkbp:PDB
|
2BYV
|
|
gptkbp:phosphorylates
|
Serine 108
Threonine 781
|
|
gptkbp:RefSeq
|
NM_139139
|
|
gptkbp:regulates
|
cell adhesion
cell junction formation
insulin secretion
vascular endothelial function
|
|
gptkbp:reviewedBy
|
gptkb:Nature
gptkb:Journal_of_Biological_Chemistry
|
|
gptkbp:role
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
|
|
gptkbp:UniProtID
|
O95398
|
|
gptkbp:bfsParent
|
gptkb:RAP1A
|
|
gptkbp:bfsLayer
|
6
|