|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alsoKnownAs
|
gptkb:Dicer
|
|
gptkbp:crystalStructureAvailable
|
yes
|
|
gptkbp:determines
|
X-ray crystallography
cryo-electron microscopy
|
|
gptkbp:discoveredBy
|
gptkb:Gregory_J._Hannon
|
|
gptkbp:domain
|
helicase domain
PAZ domain
RNase III domain
dsRNA-binding domain
|
|
gptkbp:EC_number
|
3.1.26.3
|
|
gptkbp:expressedIn
|
most human tissues
|
|
gptkbp:firstDescribed
|
2001
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
cleaves double-stranded RNA
produces microRNAs (miRNAs)
produces small interfering RNAs (siRNAs)
|
|
gptkbp:gene
|
DICER1
|
|
gptkbp:GO_term
|
GO:0004525 (ribonuclease III activity)
GO:0031050 (dsRNA processing)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Endoribonuclease Dicer
|
|
gptkbp:inhibitedBy
|
RNA viruses
viral suppressors of RNA silencing
|
|
gptkbp:interactsWith
|
gptkb:PACT
gptkb:TRBP
Argonaute proteins
|
|
gptkbp:involvedIn
|
gptkb:RNA_interference
gene silencing
|
|
gptkbp:locale
|
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
chromosome 14q32.13 (human)
|
|
gptkbp:molecularWeight
|
~219 kDa (human)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:DICER1_syndrome
|
|
gptkbp:OMIM
|
606241
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:product
|
gptkb:miRNA
gptkb:siRNA
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:requires
|
development
stem cell maintenance
siRNA biogenesis
miRNA biogenesis
|
|
gptkbp:substrate
|
double-stranded RNA
pre-microRNA
|
|
gptkbp:UniProtID
|
Q9UPY3
|
|
gptkbp:bfsParent
|
gptkb:DICER1_gene
|
|
gptkbp:bfsLayer
|
7
|